Browse our recent publications


2022_poster_ASMS_Evotec_Flenkenthaler​

Ultra-high coverage of the serum proteome using a multi-nanoparticle based workflow

This poster demonstrates ultra-high coverage of serum proteins with over 5,000 protein groups identified in a 105-sample cohort and over 3,000 protein groups identified on average per sample. Proteins were quantified at 3-5 fold higher levels compared to depleted and un-depleted serum, with 30% enhanced coverage of low abundant cytokines. This data supports a comprehensive serum proteomics workflow that can be used for patient stratification as well as potential identification of novel biomarkers which are not accessible through other strategies.
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Jun
2022

Applications:
Biomarker Discovery

Product: proteograph

2022_poster_ASMS_PrognomiQ_Khadka_Wilcox

An unbiased multi-omics approach for the detection of pancreatic cancer biomarkers utilizing ion-mobility mass spec and nanoparticle-based Proteograph technology

This poster describes a multi-omics platform facilitating the evaluation of the global proteome and lipidome in a pancreatic cancer cohort and identified multiple putative biomarker candidates across analyte classes for early disease detection.
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Jun
2022

Applications:
Cancer Research

Product: proteograph

2022_poster_ASMS_Cornell_SpaceX_Houerbi​

Deep Profiling of the Spaceflight Plasma Proteome reveals Changes in Reactive Oxygen Species, Telomeric DNA Binding, and Ribosomal Assembly and Biogenesis

This poster demonstractes how comprehensive plasma proteomics profiling of the first all-civilian astronaut crew using the Proteograph Product Suite coupled with LC-MS analysis that offers unique insights to the impact of spaceflight on human health demonstrating even short-term spaceflights can have an impact on human physiology which needs further investigation and monitoring.
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Jun
2022

Applications:
Biomarker Discovery

Product: proteograph

2022_poster_ASMS_PrognomiQ_Deyarmin

Combining Proteograph technology with Zeno SWATH DIA acquisition enables the potential for deep, unbiased discovery of biomarkers in blood

This poster demonstrates how the Proteograph Product Suite and Zeno SWATH DIA acquisition workflow that facilitates identification and quantification of thousands of proteins from human plasma without compromising throughput or reproducibility, creating a unique opportunity to detect robust protein biomarkers that translate into viable clinical tests for complex diseases.
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Jun
2022

Applications:
Cancer Research

Product: proteograph

2022 poster ASMS Alvari thumb

Deep Plasma Proteomics at Scale Enabling Precision Analyses in a Lung Cancer (NSCLC) Study

This poster demonstrates that DIA-NN, combined with the cloud-based large group run, more sensitively identifies protein groups across the cohort, which has resulted in the identification of ~4000 protein groups across a 141 NSCLC study with a microflow SWATH method and enhanced classification performance and stability with VAE, Random Forest, and SVM to AUC-ROC 0.95 compared to previous studies, leading to better biomarker discovery and disease characterization using deep and unbiased plasma proteomics analysis at scale.
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Jun
2022

Applications:
Cancer Research

Product: proteograph

2022 poster ASMS Huang

Deep, Rapid and Unbiased Plasma Proteomics with Peptide Correlation Analysis Enabling Proteoform Inference and Differential analysis in NSCLC Lung Cancer Study​

This poster demonstrates the application of the Proteograph™ Product Suite to study differentially expressed post-translational cleaved proteoforms using a modified COPF and Wilcoxon’s rank test in a NSCLC biomarker study. This study highlights the fact that differential expression are sometimes found at the peptide level and not at the protein level due to the presence of protein variants in population-scale studies.
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Jun
2022

Applications:
Cancer Research

Product: proteograph

2022 poster ASMS Benz

Deep Plasma Proteomics at Scale with Proteograph™ Product Suite: A Performance Evaluation with Label-free and TMT Multiplexing Methods

This poster demonstrates the Proteograph™ Product Suite enables rapid, automated, and reproducible sample preparation for deep plasma proteomics analysis in large cohort plasma proteomics studies.
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Jun
2022

Applications:
Assay Method

Product: proteograph

2022 poster ASMS Levitan

Evaluation of Engineered Multi-Nanoparticle-Based Proteomics Analysis for Unbiased, Deep, and Rapid Analysis of Fetal Bovine Serum Derived Cell Culture Media

This poster demonstrates the Proteograph™ Product Suite provides a deep and untargeted proteomics workflow for conditioned media with less sample volume required, enabling rapid and automated sample preparation for large-scale conditioned media proteomics analysis and enhanced proteome depth across different protein functionality.
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Jun
2022

Applications:
Assay Method

Product: proteograph

2022 poster ASMS Gajadhar

An Integrated Data Processing and Visualization Suite Leveraging Cloud Scalable Architecture for Large-Cohort Proteogenomics Data Analysis and Interpretation

This poster presents the Proteograph™ Analysis Suite (PAS), a cloud-based intuitive, scalable, data informatics solution that enables a seamless journey from raw LC-MS data to biological insight and supports automated data upload, data processing, integrated database search engines (both DIA and DDA LC-MS data), and visualization tools.
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Jun
2022

Applications:
Software

Product: proteograph

2022 poster ASMS Mohtashemi

Improving LC-MS Data Analysis Pipelines to Leverage Distributed Compute Engines

This poster demonstrates a next-generation platform capable of analyzing large cohort proteomics studies in hours, supporting fleets of LC-MS instruments by integrating legacy scoring algorithms with distributed processing infrastructure. These spark-accelerated workflows are supporting thousands of group run analyses, enabling analysis of hundreds of terabytes of LC-MS data generated in large cohort group runs.
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Jun
2022

Applications:
Computational Method

Product: proteograph

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