Publications
Browse our recent publications
Delve into scientific posters and publications that showcase the capabilities of our Proteograph technology, which has already yielded more than 36,000 multi-species proteins associated with 300,000+ sequence-confirmed measurements across 1,900+ reactome biological pathways – access our Protein Discovery Catalog for more info.
Nanoparticle-assisted proteomics of whole blood collected through multiple dried blood spot collection devices
This poster showcases how Proteograph XT enables deep, unbiased proteomic analysis of dried blood spots collected through microsampling devices, allowing rapid characterization of whole blood proteome.
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Protein coronas on functionalized nanoparticles enable quantitative and precise large-scale deep plasma proteomics
This poster demonstrates how multi-nanoparticle protein corona-based proteomics captures more proteins with accurate fold-changes, linearity, and precision compared to neat digestion plasma workflow.
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Human biofluids analysis using a scalable, deep, unbiased, automated, nanoparticle-based proteomics platform
This poster demonstrates how the Proteograph XT Assay is interrogating a variety of human biofluid samples, including CSF and CM, simplifying the analysis of biofluids without the need for complex sample manipulation and fractionation, offering a robust solution for deep proteomic analysis and biological insights.
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Plasma proteomic landscape of Alzheimer’s disease: An 1800-sample cohort study
This poster demonstrates scaling a proteomics study of Alzheimer’s disease (AD) cohort using a new, high-throughput Proteograph™ XT Assay in development enables powerful insights into AD biology. (>5000 protein group IDs across a ~1800 subject AD cohort study.)
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Deep, unbiased and quantitative mass spectrometry-based plasma proteome analyses of adaptive response to COVID-19 vaccine
This poster demonstrates the Proteograph™ workflow performance, in combination with TMT 18-Plex, provides much deeper access to human plasma proteome (i.e., 3,094 proteins), and reveals insights into the inter-individual variation of response to the COVID-19 vaccination.
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Multi-omics data integration reveals clinical associated biomolecules in type 2 diabetes
This poster demonstrates how the Proteograph™ workflow enables large-scale quantification of plasma proteins, providing unprecedented deep proteome profiling for multi-omics integration in type 2 diabetes.
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High-throughput plasma proteomics to identify diabetes associated protein biomarkers and pQTLs
This poster demonstrates the assessment of various methods to roll peptides to protein groups for the Proteograph™ workflow with DIA LC-MS analysis and the potential impact on downstream bioinformatics analysis and biological insight.
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Evaluation of an unbiased, deep, and scalable multi nanoparticle-based proteomics workflow for limited plasma sample volume from model organisms
This poster demonstrates the application of the Proteograph™ workflow to non-standard, low starting volume samples like low-volume mouse plasma samples.
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Dissecting the formation of protein corona on nanoparticles allows reconstructing deep plasma protein concentrations and discovering novel proteoforms
This poster demonstrates how profiling the Proteograph™ workflow provides a novel high-throughput approach to estimate biophysical properties of plasma proteins and individual proteoforms.
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Building spectral libraries to enable large-scale quantitative proteomic studies in human plasma
This poster demonstrates a comprehensive spectral library approach enabling high-throughput human plasma proteomics.
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