Browse our recent publications


USHUPO22_prognomic_thumb

Incorporation of Glycoproteome Detection into Large Scale Unbiased Proteomics Studies Utilizing Nanoparticles

This poster, presented at USHUPO from Prognomiq describes how Seer’s Proteograph™ nanoparticle technology specifically captures unique proteoforms in the corona formation and allow for comprehensive assessment of the circulating glycoproteome.
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Mar
2022

Area of interest:
Assay Method
Cancer Research

Product: proteograph

deep proteomics studies at scale

Engineered nanoparticles enable deep proteomics studies at scale by leveraging tunable nano–bio interactions

This study examines in detail the relationship between the unique physicochemical properties of a panel of proprietary engineered nanoparticles (NPs) and the diverse pattern of protein sampling that is enabled by a unique nano-bio interface that is created between a given NP surface and a given biological sample.
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Mar
2022

Area of interest:
Assay Method

Product: proteograph

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Deep and Unbiased Plasma Profiling of Alzheimer’s and Mild Cognitive Impairment Subjects with a Novel Multi-nanoparticle Approach

This work, presented at USHUPO, describes a 200-sample study to classify protein biomarkers for AD and MCI conditions in a rapid, reproducible fashion to enable more powerful clinical studies.
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Mar
2022

Area of interest:
Neurodegenerative Disease

Product: proteograph

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Deep, Rapid and Unbiased Plasma Proteomics with Differential Analysis of Proteoforms Enabling Proteogenomic Studies in a NSCLC Study

This poster, presented at USHUPO describes a performance evaluation between label-free and tandem mass tag multiplex methods for plasma proteomics. The Proteograph Product Suite enables rapid, automated and reproducible sample prep for larger sample cohorts.
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Mar
2022

Area of interest:
Cancer Research

Product: proteograph

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Deep Plasma Proteomics at Scale Enabling Proteogenomic Analysis in a Lung Cancer (NSCLC) Study

This poster demonstrates a DIA-NN approach combined with the cloud-based large group run more sensitively identifies protein groups across the cohort (~4000 vs the previous ~2,500), enabling development of improved classification models and marker discovery.
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Mar
2022

Area of interest:
Cancer Research

Product: proteograph

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Cloud-scalable Software Suite for Large-Scale Proteogenomics Data Analysis and Visualization

Presented at USHUPO 2022, this poster provides an overview of Seer’s comprehensive proteomic analysis software to enable user-friendly, reproducible multi-omics analyses of proteomic and genomic data.
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Mar
2022

Area of interest:
Software

Product: proteograph

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Multi-nanoparticle Workflow Enables Deep Plasma Proteomics at Scale with Enhanced Precision and Depth of Coverage

Presented at USHUPO 2022, this study describes how nano-bio interactions may be tuned to optimize the binding and capture of a large and diverse set of proteins, including cytokines and hormone signaling proteins.
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Mar
2022

Area of interest:
Assay Method

Product: proteograph

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Deep Plasma Proteomics at Scale with Proteograph™ Product Suite: A Performance Evaluation with Label-free and TMT Multiplexing Methods

This poster, presented at USHUPO 2022 describes a comparison of performance between label-free Data Dependent Acquisition (DDA) and TMT multiplexing methods with a set of control plasma samples processed with Proteograph Product Suite for deep plasma proteomic analysis.
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Mar
2022

Area of interest:
Assay Method

Product: proteograph

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Characterizing and Correcting Batch Effects in Large Scale Proteomics Data

Presented at USHUPO 2022, this study compares several techniques for characterizing batch effects, including PCA analysis, local-neighborhood diversity measures, and ML classifier-based methods.
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Mar
2022

Area of interest:
Computational Method

Product: proteograph

Biorxiv_-2022_Donovan

Peptide-centric analyses of human plasma enable increased resolution of biological insights into non-small cell lung cancer relative to protein-centric analysis

This article demonstrates the utility of combined unbiased proteomics with transcriptomic analysis, and identified over 400 subject-specific protein variants, showing how the Proteograph Product Suite can support proteogenomics studies.
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Jan
2022

Area of interest:
Cancer Research

Product: proteograph

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