Publications
Browse our recent publications
Protein coronas on functionalized nanoparticles enable quantitative and precise large-scale deep plasma proteomics
This poster demonstrates how multi-nanoparticle protein corona-based proteomics captures more proteins with accurate fold-changes, linearity, and precision compared to neat digestion plasma workflow.
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Human biofluids analysis using a scalable, deep, unbiased, automated, nanoparticle-based proteomics platform
This poster demonstrates how the Proteograph XT Assay is interrogating a variety of human biofluid samples, including CSF and CM, simplifying the analysis of biofluids without the need for complex sample manipulation and fractionation, offering a robust solution for deep proteomic analysis and biological insights.
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Plasma proteomic landscape of Alzheimer’s disease: An 1800-sample cohort study
This poster demonstrates scaling a proteomics study of Alzheimer’s disease (AD) cohort using a new, high-throughput Proteograph™ XT Assay in development enables powerful insights into AD biology. (>5000 protein group IDs across a ~1800 subject AD cohort study.)
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Deep, unbiased and quantitative mass spectrometry-based plasma proteome analyses of adaptive response to COVID-19 vaccine
This poster demonstrates the Proteograph™ workflow performance, in combination with TMT 18-Plex, provides much deeper access to human plasma proteome (i.e., 3,094 proteins), and reveals insights into the inter-individual variation of response to the COVID-19 vaccination.
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Multi-omics data integration reveals clinical associated biomolecules in type 2 diabetes
This poster demonstrates how the Proteograph™ workflow enables large-scale quantification of plasma proteins, providing unprecedented deep proteome profiling for multi-omics integration in type 2 diabetes.
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High-throughput plasma proteomics to identify diabetes associated protein biomarkers and pQTLs
This poster demonstrates the assessment of various methods to roll peptides to protein groups for the Proteograph™ workflow with DIA LC-MS analysis and the potential impact on downstream bioinformatics analysis and biological insight.
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Evaluation of an unbiased, deep, and scalable multi nanoparticle-based proteomics workflow for limited plasma sample volume from model organisms
This poster demonstrates the application of the Proteograph™ workflow to non-standard, low starting volume samples like low-volume mouse plasma samples.
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Dissecting the formation of protein corona on nanoparticles allows reconstructing deep plasma protein concentrations and discovering novel proteoforms
This poster demonstrates how profiling the Proteograph™ workflow provides a novel high-throughput approach to estimate biophysical properties of plasma proteins and individual proteoforms.
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Building spectral libraries to enable large-scale quantitative proteomic studies in human plasma
This poster demonstrates a comprehensive spectral library approach enabling high-throughput human plasma proteomics.
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Proteoform detection in deep plasma proteomics through peptide expression correlation
This poster demonstrates how the Proteograph™ workflow generates unbiased and deep plasma proteome profiles in large sample cohorts, enabling the inference of biologically important proteoforms.
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