Browse our recent publications

Delve into scientific posters and publications that showcase the capabilities of our Proteograph technology, which has already yielded more than 10,000 proteins associated with 100,000+ possible biomarkers across 1,900 reactome biological pathways – access our Protein Discovery Catalog for more info.


Protein coronas on functionalized nanoparticles enable quantitative and precise large-scale deep plasma proteomics

Protein coronas on functionalized nanoparticles enable quantitative and precise large-scale deep plasma proteomics

This poster demonstrates how multi-nanoparticle protein corona-based proteomics captures more proteins with accurate fold-changes, linearity, and precision compared to neat digestion plasma workflow.
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Sep
2023

Applications:
Biomarker Discovery

Human biofluids analysis using a scalable, deep, unbiased, automated, nanoparticle-based proteomics platform

Human biofluids analysis using a scalable, deep, unbiased, automated, nanoparticle-based proteomics platform

This poster demonstrates how the Proteograph XT Assay is interrogating a variety of human biofluid samples, including CSF and CM, simplifying the analysis of biofluids without the need for complex sample manipulation and fractionation, offering a robust solution for deep proteomic analysis and biological insights.
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Sep
2023

Applications:
Biomarker Discovery

Plasma proteomic landscape of Alzheimer’s disease: An 1800-sample cohort study

Plasma proteomic landscape of Alzheimer’s disease: An 1800-sample cohort study

This poster demonstrates scaling a proteomics study of Alzheimer’s disease (AD) cohort using a new, high-throughput Proteograph™ XT Assay in development enables powerful insights into AD biology. (>5000 protein group IDs across a ~1800 subject AD cohort study.)
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Sep
2023

Applications:
Neurodegenerative Disease

Product: proteograph

Deep, unbiased and quantitative mass spectrometry-based plasma proteome analyses of adaptive response to COVID-19 vaccine

Deep, unbiased and quantitative mass spectrometry-based plasma proteome analyses of adaptive response to COVID-19 vaccine

This poster demonstrates the Proteograph™ workflow performance, in combination with TMT 18-Plex, provides much deeper access to human plasma proteome (i.e., 3,094 proteins), and reveals insights into the inter-individual variation of response to the COVID-19 vaccination.
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Jun
2023

Applications:
Biomarker Discovery

Product: proteograph

Multi-omics data integration reveals clinical associated biomolecules in type 2 diabetes

Multi-omics data integration reveals clinical associated biomolecules in type 2 diabetes

This poster demonstrates how the Proteograph™ workflow enables large-scale quantification of plasma proteins, providing unprecedented deep proteome profiling for multi-omics integration in type 2 diabetes.
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Jun
2023

Applications:
Biomarker Discovery

Product: proteograph

High-throughput plasma proteomics to identify diabetes associated protein biomarkers and pQTLs

High-throughput plasma proteomics to identify diabetes associated protein biomarkers and pQTLs

This poster demonstrates the assessment of various methods to roll peptides to protein groups for the Proteograph™ workflow with DIA LC-MS analysis and the potential impact on downstream bioinformatics analysis and biological insight.
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Jun
2023

Applications:
Computational Method

Product: proteograph

Evaluation of an unbiased, deep, and scalable multi nanoparticle-based proteomics workflow for limited plasma sample volume from model organisms

Evaluation of an unbiased, deep, and scalable multi nanoparticle-based proteomics workflow for limited plasma sample volume from model organisms

This poster demonstrates the application of the Proteograph™ workflow to non-standard, low starting volume samples like low-volume mouse plasma samples.
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Jun
2023

Applications:
Assay Method

Product: proteograph

Dissecting the formation of protein corona on nanoparticles allows reconstructing deep plasma protein concentrations and discovering novel proteoforms

Dissecting the formation of protein corona on nanoparticles allows reconstructing deep plasma protein concentrations and discovering novel proteoforms

This poster demonstrates how profiling the Proteograph™ workflow provides a novel high-throughput approach to estimate biophysical properties of plasma proteins and individual proteoforms.
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Jun
2023

Applications:
Computational Method

Product: proteograph

Building spectral libraries to enable large-scale quantitative proteomic studies in human plasma

Building spectral libraries to enable large-scale quantitative proteomic studies in human plasma

This poster demonstrates a comprehensive spectral library approach enabling high-throughput human plasma proteomics.
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Jun
2023

Applications:
Computational Method

Product: proteograph

Proteoform detection in deep plasma proteomics through peptide expression correlation

Proteoform detection in deep plasma proteomics through peptide expression correlation

This poster demonstrates how the Proteograph™ workflow generates unbiased and deep plasma proteome profiles in large sample cohorts, enabling the inference of biologically important proteoforms.
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Jun
2023

Applications:
Computational Method

Product: proteograph