Backed by decades of research in nanoparticles, the nano-bio interface, machine learning, and systems biology, our Proteograph® Product Suite accelerates breakthroughs to overcome the challenges of complex biological matrices and low-abundance targets to deliver the increased depth, accuracy, and scalability needed to drive breakthroughs in drug development, disease research, and precision medicine.
What is a nanoparticle (NP)?
A nanoparticle (NP) is usually defined as a particle that is less than 500 nanometers in diameter (significantly smaller than a particle). NPs have been used in a wide range of diverse applications, including medicine (nanomedicine), biotechnology and pharmaceuticals, energy, electronics and communications, automobiles/machinery, chemistry and materials, and environmental testing.
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Request more infoHow do nanoparticles behave in a biological medium?
When nanoparticles are placed in contact with a biological sample, a thin layer of intact proteins rapidly, selectively, and reproducibly absorb onto the surface of a nanoparticle upon contact, forming what is called a protein “corona”.
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Request more infoCan nanoparticles be tuned to modify the composition of the protein corona?
The composition and quantity of the corona proteins depend on the physicochemical properties of the NPs and the surface. Properties like nanoparticle size, shape, material, charge, porosity, as well as surface functional groups will impact corona composition.
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Request more infoHow do nanoparticles enable broad and deep coverage of the plasma proteome?
When nanoparticles come into contact with proteins in a biofluid, based on the nanoparticles’ tuned physicochemical properties, a highly reproducible and robust protein corona will form containing proteins spanning the wide dynamic range of the plasma proteome. The dynamic range is quantitatively compressed as a function of relative affinities and protein concentrations. With the use of a panel of several diverse nanoparticles, the resulting protein coronas will cumulatively result in broad and deep coverage of the plasma proteome.
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Request more infoWhat makes Seer’s engineered nanoparticles unique? What are they used for?
Seer’s engineered nanoparticles (NPs) consist of a magnetic core and a surface with unique physicochemical properties. When nanoparticles are introduced into a biofluid, such as blood plasma, a selective and reproducible protein corona is formed at the nano-bio interface, driven by a combination of protein-nanoparticle affinity, protein abundance, and protein-protein interactions.
Panels of these proprietary engineered NPs have been designed to efficiently and robustly sample the physicochemical space of the entire proteome, compressing the dynamic range quantitatively to render biological information more accessible for any downstream detector.
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Request more infoStarting your proteomics research is effortless
Connect with an expert to discuss which path to the full proteome is right for you.
