Browse our recent publications


USHUPO_2022_Huang_thumb

Deep, Rapid and Unbiased Plasma Proteomics with Differential Analysis of Proteoforms Enabling Proteogenomic Studies in a NSCLC Study

This poster, presented at USHUPO describes a performance evaluation between label-free and tandem mass tag multiplex methods for plasma proteomics. The Proteograph Product Suite enables rapid, automated and reproducible sample prep for larger sample cohorts.
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Mar
2022

Applications:
Cancer Research

Product: proteograph

USHUPO_2022_Ferdosi_thumb

Multi-nanoparticle Workflow Enables Deep Plasma Proteomics at Scale with Enhanced Precision and Depth of Coverage

Presented at USHUPO 2022, this study describes how nano-bio interactions may be tuned to optimize the binding and capture of a large and diverse set of proteins, including cytokines and hormone signaling proteins.
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Mar
2022

Applications:
Assay Method

Product: proteograph

Biorxiv_-2022_Donovan

Peptide-centric analyses of human plasma enable increased resolution of biological insights into non-small cell lung cancer relative to protein-centric analysis

This article demonstrates the utility of combined unbiased proteomics with transcriptomic analysis, and identified over 400 subject-specific protein variants, showing how the Proteograph Product Suite can support proteogenomics studies.
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Jan
2022

Applications:
Cancer Research

Product: proteograph

Biorxiv_2022_Hornburg

Enhanced competitive protein exchange at the nano-bio interface enables ultra-deep coverage of the human plasma proteome

This article explores the unique capacity of nanoparticles, a key component of the Proteograph Product Suite, to be tuned to interact with proteins by tailored surface functionalization and optimized to enable deeper protein access.
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Jan
2022

Applications:
Assay Method

Product: proteograph

In-Depth Plasma Proteomics Profiling With Nanoparticle-Based Proteograph Workflow: A Performance Evaluation Of Label-Free And TMT Multiplexing Approaches

In-Depth Plasma Proteomics Profiling With Nanoparticle-Based Proteograph Workflow: A Performance Evaluation Of Label-Free And TMT Multiplexing Approaches

This poster presented at the American Society for Mass Spectrometry describes a high-throughput multiplexed workflow for 16 biofluid samples. Plasma proteins across 9 orders of magnitude dynamic range including 40 cytokine activity proteins and several members of the TNF superfamily were identified.
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Nov
2021

Applications:
Assay Method

Product: proteograph

Nanoparticle-Based Method Identifies 2200 Proteins In A Cardiovascular Disease Study Covering Known Biomarkers Among Other Differentially Expressed Proteins

Nanoparticle-Based Method Identifies 2200 Proteins In A Cardiovascular Disease Study Covering Known Biomarkers Among Other Differentially Expressed Proteins

This collaboration with the Broad Institute presented at the American Society for Mass Spectrometry describes a Proteograph™ application for cardiovascular biomarker research using deep plasma proteomics. Over 2000 proteins were detected in each individual patient sample with a total of over 4000 across 16 samples.
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Nov
2021

Applications:
Cardiovascular Research

Product: proteograph

Proteomic Profiling Of Prostate Cancer Plasma Specimens Using Proteograph And TIMS Technology

Proteomic Profiling Of Prostate Cancer Plasma Specimens Using Proteograph And TIMS Technology

This poster presented at the American Society for Mass Spectrometry from Oregon Health Sciences University describes a Proteograph™ application proof-of-concept pilot study on 32 prostate cancer serum specimens retrospectively collected from patients with high and low tumor grades.
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Nov
2021

Applications:
Cancer Research

Product: proteograph

The utility of nanoparticle protein coronas for studying the plasma glycoproteome

The utility of nanoparticle protein coronas for studying the plasma glycoproteome

This collaboration between Seer and Protein Metrics presented at the American Society for Mass Spectrometry describes the formation of NP protein coronas that enable analysis of subpopulations of the glycoproteome without the need for subsequent, glycopeptide-specific enrichment.
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Nov
2021

Applications:
Assay Method

Product: proteograph

Cloud scalable omics data analysis pipeline using serverless task infrastructure

Cloud scalable omics data analysis pipeline using serverless task infrastructure

This poster presented at the American Society for Mass Spectrometry describes the Proteograph™  Analysis Suite featuring multiple, integrated MS/MS database search engines including MaxQuant and DIA-NN, with automatic results generation, QC tools to evaluate data quality, and differential expression analysis for seamless generation of proteomics results.
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Nov
2021

Applications:
Computational Method

Product: proteograph

Mass spectrometry data acquisition with machine learning methods for deep plasma protein characterization

Mass spectrometry data acquisition with machine learning methods for deep plasma protein characterization

This poster describes an informed MS acquisition strategy improving sample-specific peptide/protein identification rates as well as reduced DDA stochasticity in repeated injections. The workflow leverages Seer’s current nanoparticles and generalized enrichment behaviors to inform MS instruments to increase orthogonality across panels maximizing ID rates.
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Nov
2021

Applications:
Computational Method

Product: proteograph