Browse our recent publications


2022 poster ASMS Levitan

Evaluation of Engineered Multi-Nanoparticle-Based Proteomics Analysis for Unbiased, Deep, and Rapid Analysis of Fetal Bovine Serum Derived Cell Culture Media

This poster demonstrates the Proteograph™ Product Suite provides a deep and untargeted proteomics workflow for conditioned media with less sample volume required, enabling rapid and automated sample preparation for large-scale conditioned media proteomics analysis and enhanced proteome depth across different protein functionality.
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Jun
2022

Applications:
Assay Method

Product: proteograph

2022 poster ASMS Gajadhar

An Integrated Data Processing and Visualization Suite Leveraging Cloud Scalable Architecture for Large-Cohort Proteogenomics Data Analysis and Interpretation

This poster presents the Proteograph™ Analysis Suite (PAS), a cloud-based intuitive, scalable, data informatics solution that enables a seamless journey from raw LC-MS data to biological insight and supports automated data upload, data processing, integrated database search engines (both DIA and DDA LC-MS data), and visualization tools.
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Jun
2022

Applications:
Software

Product: proteograph

2022 poster ASMS Mohtashemi

Improving LC-MS Data Analysis Pipelines to Leverage Distributed Compute Engines

This poster demonstrates a next-generation platform capable of analyzing large cohort proteomics studies in hours, supporting fleets of LC-MS instruments by integrating legacy scoring algorithms with distributed processing infrastructure. These spark-accelerated workflows are supporting thousands of group run analyses, enabling analysis of hundreds of terabytes of LC-MS data generated in large cohort group runs.
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Jun
2022

Applications:
Computational Method

Product: proteograph

2022 poster ASMS Alvari thumb

Challenges in Large Scale Proteomics Data Analysis: A Survey of Characterization and Correction Solutions for Batch Effects

This poster demonstrates batch effects can contribute to a large amount of the noise in large-scale proteomics datasets compared to biological variations, but deep learning approaches have the ability to integrate diverse proteomics datasets, and the extension of DANN can harmonize data across technical factors while maintaining the fidelity of the biological signal in the data.
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Jun
2022

Applications:
Computational Method

Product: proteograph

2022 poster ASMS Chu

Robust In-depth Label-free Plasma Proteomics with Engineered Nanoparticle Panels: An Evaluation of Micro-pillar Array Columns and FAIMS Peptide Separation

This poster demonstrates the Proteograph™ Product Suite facilitates access to lower abundant proteins in the plasma proteome compared to neat plasma digestion, for high-throughput unbiased plasma proetomics analysis.
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Jun
2022

Applications:
Assay Method

Product: proteograph

2022 poster ASMS Castro

Robust, High Throughput and Deep Plasma Proteomics Workflow with Engineered Nanoparticle Panels

This poster demonstrates the Proteograph™ Product Suite provides a significant increase in the peptide group and protein group counts versus neat plasma, using a robust high throughput 33min microflow DIA method.
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Jun
2022

Applications:
Assay Method

Product: proteograph

Deep, Unbiased Multi-omics Approach for the Identification of Pancreatic Cancer Biomarkers from Blood

Deep, Unbiased Multi-omics Approach for the Identification of Pancreatic Cancer Biomarkers from Blood

This poster, presented at AACR 2022 from Prognomiq, describes a proof-of-concept study using broad phenotypic multi-omics approach to identify known and unknown biomarkers in a pancreatic cancer cohort.
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May
2022

Applications:
Assay Method
Cancer Research

Product: proteograph

USHUPO22_prognomic_thumb

Incorporation of Glycoproteome Detection into Large Scale Unbiased Proteomics Studies Utilizing Nanoparticles

This poster, presented at USHUPO from Prognomiq describes how Seer’s Proteograph™ nanoparticle technology specifically captures unique proteoforms in the corona formation and allow for comprehensive assessment of the circulating glycoproteome.
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Mar
2022

Applications:
Assay Method
Cancer Research

Product: proteograph

deep proteomics studies at scale

Engineered nanoparticles enable deep proteomics studies at scale by leveraging tunable nano–bio interactions

This study examines in detail the relationship between the unique physicochemical properties of a panel of proprietary engineered nanoparticles (NPs) and the diverse pattern of protein sampling that is enabled by a unique nano-bio interface that is created between a given NP surface and a given biological sample.
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Mar
2022

Applications:
Assay Method

Product: proteograph

USHUPO_2022_Siddiqui_thumb

Deep and Unbiased Plasma Profiling of Alzheimer’s and Mild Cognitive Impairment Subjects with a Novel Multi-nanoparticle Approach

This work, presented at USHUPO, describes a 200-sample study to classify protein biomarkers for AD and MCI conditions in a rapid, reproducible fashion to enable more powerful clinical studies.
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Mar
2022

Applications:
Neurodegenerative Disease

Product: proteograph