This poster demonstrates how the NP-based proteomics workflow enables the investigation of plasma glycoproteome without subsequent enrichment of glycopeptides while facilitating deep access to the proteome.
This poster demonstrates how the Proteograph™ Product Suite workflow, with the label-free DIA mass spectrometry method, provides highly reproducible proteomics data for large-scale plasma proteomics analysis. (i.e., > 19,000 unique peptides, >2,500 unique protein groups covering broadly and deeply in HPPP database, and for both intra- and inter-batch comparison, peptide intensity CVs < 20% and protein group JI >= 0.85.)
This study uses the Proteograph™ Product Suite to perform a pQTL analysis, and highlights the advantages of Proteograph workflow for identifiying protein altering variants with clinical relevance that may not be detectable using affinity-based methods.
Identification of protein isoforms in a non-small cell lung cancer cohort shows functionally distinct, cancer- and control-associated isoforms, including BMP1. This article demonstrates the utility of combined unbiased proteomics with transcriptomic analysis, and identified over 400 subject-specific protein variants, showing how the Proteograph Product Suite can support proteogenomics studies.
This poster demonstrates the application of the Proteograph™ workflow for various biofluids samples (plasma, serum, urine, CSF, and conditioned media), its superior performance compared to the neat digestion workflow, and the potential insights it can reveal.