This poster demonstrates how the NP-based proteomics workflow enables the investigation of plasma glycoproteome without subsequent enrichment of glycopeptides while facilitating deep access to the proteome.
This poster demonstrates the comparison of machine learning algorithms for Alzheimer’s disease classification and demonstration of SeerML, an AutoML classifier achieving an enhanced AUC of 0.80.
This poster demonstrates how the Proteograph™ Product Suite workflow, with the label-free DIA mass spectrometry method, provides highly reproducible proteomics data for large-scale plasma proteomics analysis. (i.e., > 19,000 unique peptides, >2,500 unique protein groups covering broadly and deeply in HPPP database, and for both intra- and inter-batch comparison, peptide intensity CVs < 20% and protein group JI >= 0.85.)
This poster demonstrates how applying image classification directly on raw MS1 data shows great accuracy for nanoparticle-based sample processing quality control using raw MS data.
This study uses the Proteograph™ Product Suite to perform a pQTL analysis, and highlights the advantages of Proteograph workflow for identifiying protein altering variants with clinical relevance that may not be detectable using affinity-based methods.
Identification of protein isoforms in a non-small cell lung cancer cohort shows functionally distinct, cancer- and control-associated isoforms, including BMP1. This article demonstrates the utility of combined unbiased proteomics with transcriptomic analysis, and identified over 400 subject-specific protein variants, showing how the Proteograph Product Suite can support proteogenomics studies.
This poster demonstrates the application of the Proteograph™ workflow to non-standard, low starting volume samples, such as low volume mouse plasma samples.
This poster demonstrates the application of the Proteograph™ workflow for various biofluids samples (plasma, serum, urine, CSF, and conditioned media), its superior performance compared to the neat digestion workflow, and the potential insights it can reveal.