Browse our recent publications


2022 poster ASMS Alvari thumb

Challenges in Large Scale Proteomics Data Analysis: A Survey of Characterization and Correction Solutions for Batch Effects

This poster demonstrates batch effects can contribute to a large amount of the noise in large-scale proteomics datasets compared to biological variations, but deep learning approaches have the ability to integrate diverse proteomics datasets, and the extension of DANN can harmonize data across technical factors while maintaining the fidelity of the biological signal in the data.
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Jun
2022

Applications:
Computational Method

Product: proteograph

2022 poster ASMS Chu

Robust In-depth Label-free Plasma Proteomics with Engineered Nanoparticle Panels: An Evaluation of Micro-pillar Array Columns and FAIMS Peptide Separation

This poster demonstrates the Proteograph™ Product Suite facilitates access to lower abundant proteins in the plasma proteome compared to neat plasma digestion, for high-throughput unbiased plasma proetomics analysis.
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Jun
2022

Applications:
Assay Method

Product: proteograph

2022 poster ASMS Castro

Robust, High Throughput and Deep Plasma Proteomics Workflow with Engineered Nanoparticle Panels

This poster demonstrates the Proteograph™ Product Suite provides a significant increase in the peptide group and protein group counts versus neat plasma, using a robust high throughput 33min microflow DIA method.
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Jun
2022

Applications:
Assay Method

Product: proteograph

Deep, Unbiased Multi-omics Approach for the Identification of Pancreatic Cancer Biomarkers from Blood

Deep, Unbiased Multi-omics Approach for the Identification of Pancreatic Cancer Biomarkers from Blood

This poster, presented at AACR 2022 from Prognomiq, describes a proof-of-concept study using broad phenotypic multi-omics approach to identify known and unknown biomarkers in a pancreatic cancer cohort.
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May
2022

Applications:
Assay Method
Cancer Research

Product: proteograph

USHUPO22_prognomic_thumb

Incorporation of Glycoproteome Detection into Large Scale Unbiased Proteomics Studies Utilizing Nanoparticles

This poster, presented at USHUPO from Prognomiq describes how Seer’s Proteograph™ nanoparticle technology specifically captures unique proteoforms in the corona formation and allow for comprehensive assessment of the circulating glycoproteome.
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Mar
2022

Applications:
Assay Method
Cancer Research

Product: proteograph

deep proteomics studies at scale

Engineered nanoparticles enable deep proteomics studies at scale by leveraging tunable nano–bio interactions

This study examines in detail the relationship between the unique physicochemical properties of a panel of proprietary engineered nanoparticles (NPs) and the diverse pattern of protein sampling that is enabled by a unique nano-bio interface that is created between a given NP surface and a given biological sample.
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Mar
2022

Applications:
Assay Method

Product: proteograph

USHUPO_2022_Siddiqui_thumb

Deep and Unbiased Plasma Profiling of Alzheimer’s and Mild Cognitive Impairment Subjects with a Novel Multi-nanoparticle Approach

This work, presented at USHUPO, describes a 200-sample study to classify protein biomarkers for AD and MCI conditions in a rapid, reproducible fashion to enable more powerful clinical studies.
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Mar
2022

Applications:
Neurodegenerative Disease

Product: proteograph

USHUPO_2022_Huang_thumb

Deep, Rapid and Unbiased Plasma Proteomics with Differential Analysis of Proteoforms Enabling Proteogenomic Studies in a NSCLC Study

This poster, presented at USHUPO describes a performance evaluation between label-free and tandem mass tag multiplex methods for plasma proteomics. The Proteograph Product Suite enables rapid, automated and reproducible sample prep for larger sample cohorts.
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Mar
2022

Applications:
Cancer Research

Product: proteograph

USHUPO_2022_Ferdosi_thumb

Multi-nanoparticle Workflow Enables Deep Plasma Proteomics at Scale with Enhanced Precision and Depth of Coverage

Presented at USHUPO 2022, this study describes how nano-bio interactions may be tuned to optimize the binding and capture of a large and diverse set of proteins, including cytokines and hormone signaling proteins.
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Mar
2022

Applications:
Assay Method

Product: proteograph

Biorxiv_-2022_Donovan

Peptide-centric analyses of human plasma enable increased resolution of biological insights into non-small cell lung cancer relative to protein-centric analysis

This article demonstrates the utility of combined unbiased proteomics with transcriptomic analysis, and identified over 400 subject-specific protein variants, showing how the Proteograph Product Suite can support proteogenomics studies.
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Jan
2022

Applications:
Cancer Research

Product: proteograph