This poster showcases how Proteograph XT enables deep, unbiased proteomic analysis of dried blood spots collected through microsampling devices, allowing rapid characterization of whole blood proteome.

This poster demonstrates how multi-nanoparticle protein corona-based proteomics captures more proteins with accurate fold-changes, linearity, and precision compared to neat digestion plasma workflow.

This poster demonstrates how the Proteograph XT Assay is interrogating a variety of human biofluid samples, including CSF and CM, simplifying the analysis of biofluids without the need for complex sample manipulation and fractionation, offering a robust solution for deep proteomic analysis and biological insights.

This poster demonstrates scaling a proteomics study of Alzheimer’s disease (AD) cohort using a new, high-throughput Proteograph™ XT Assay in development enables powerful insights into AD biology. (>5000 protein group IDs across a ~1800 subject AD cohort study.)

This poster demonstrates the Proteograph™ workflow performance, in combination with TMT 18-Plex, provides much deeper access to human plasma proteome (i.e., 3,094 proteins), and reveals insights into the inter-individual variation of response to the COVID-19 vaccination.

This poster demonstrates how the Proteograph™ workflow enables large-scale quantification of plasma proteins, providing unprecedented deep proteome profiling for multi-omics integration in type 2 diabetes.

This poster demonstrates the assessment of various methods to roll peptides to protein groups for the Proteograph™ workflow with DIA LC-MS analysis and the potential impact on downstream bioinformatics analysis and biological insight.

This poster demonstrates the application of the Proteograph™ workflow to non-standard, low starting volume samples like low-volume mouse plasma samples.

This poster demonstrates how profiling the Proteograph™ workflow provides a novel high-throughput approach to estimate biophysical properties of plasma proteins and individual proteoforms.

This poster demonstrates a comprehensive spectral library approach enabling high-throughput human plasma proteomics.