December 14, 2022 | Customer Poster
A Highly-Scaled Proteomic Discovery Study for Prostate Cancer Diagnostic Signatures Using Proteograph Technology With Trapped Ion Mobility Mass Spectrometry
Human Proteome Organization – Mark Flory, et al.
This poster highlights current challenges in large-scale DIA data analysis and evaluates the impact of various spectral library approaches. The study leverages the Proteograph workflow and Bruker timsTOF platforms to investigate ~900 patient serum samples with controls.
Prostate Cancer Diagnostic Goal
- Problem: Current standard-of-care prostate cancer diagnosis using PSA blood testing exhibits low specificity for cancer and leads to unwarranted prostate biopsy.
- Goal: Our study seeks to discover new proteomic PSA reflex markers in blood with increased specificity for total and high-grade prostate cancer.
- Approach: We leverage a novel multi nanoparticle based, deep and scalable proteomics platform to investigate ~900 patient serum samples and controls.
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