Mass Spectrometry Scientist

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Seer is seeking up to three (3) experienced Scientists to join the Mass Spectrometry group.  This group will be comprised of Scientists and Research Associates reporting to the Senior Director, Mass Spectrometry. They will implement current methods as well as develop new methods for proteomics molecular profiling leveraging Seer’s proprietary technology platform and the latest generation of MS instrumentation. The driving focus of this team, working closely with the data science group as well as adjacent bioassay and clinical operations groups, is to acquire as much molecular profiling data as possible from Seer-technology derived samples in order to develop information that is key to a variety of downstream utility and value propositions.

RESPONSIBILITIES

The mass spectrometry group will use the latest MS and associated instrumentation for proteomics molecular profiling. The job specific responsibilities are::

  • Carefully perform procedures on experimental samples derived from blood and blood products, urine, saliva, and other biological fluids or tissues.
  • Manage lab activities, including routine calculations, data entry, and lab notebook maintenance.
  • Operate sophisticated analytical equipment including HPLCs and mass spectrometers.
  • Own the design, development, and implementation of MS-based assays and workflows used for biomarker discovery.
  • Organize, evaluate, and communicate data in an effective and scientific manner.
  • Interact with company leadership to develop Seer’s scientific strategy.
  • Work closely with the data science group as well as interact, collaborate, and support other functional teams within the broader Seer Research, Development, and Clinical framework.

QUALIFICATIONS

The successful candidate will have relevant and extensive experience in an academic or life sciences industry laboratory equipped with sophisticated instrumentation such as mass spectrometers, HPLC, and/or liquid handling robotics. The ideal candidate will have 5+ years of direct experience with the use, management, and maintenance of mass spectrometers and associated instruments.

The candidate must bring teamwork skills, an attention to detail, superior productivity, a strong entrepreneurial orientation, and absolute commitment to competing with the highest level of integrity to their work at Seer. They must be able to carry out detailed experimental protocols as well as play a leading role in the development of such protocols. They must be able to clearly and appropriately report on their work, as well as have an understanding of how their work fits in with and impacts the work of other colleagues and teams within the Seer Research, Development, and Clinical framework.

Requirements include:

  • A PhD in a bench laboratory scientific discipline such as biochemistry, molecular biology, or analytical chemistry.
  • Minimum 3 years experience (5+ preferred) in an academic or life-sciences industry laboratory setting (biotech start-up experience preferred).
  • Experience with a variety of relative and absolute quantitation techniques, such as TMT and label-free strategies, as well as targeted studies using SRM/MRM.
  • Extensive hands-on experience operating LC-MS/MS systems, including the latest generation of SCIEX and Thermo instrumentation.
  • Strong written and oral communications skills, with demonstrated experience in cross-functional and timely communication.  A track record of peer-reviewed publications and presentations at international science conferences is preferred.
  • Strong and collaborative work ethic; must be a self-starter and persistent in achieving objectives to support Seer’s scientific and business goals.
  • Superior critical thinking skills, a high level of creativity, and the ability to adapt and thrive in a rapidly growing start-up.  Must work well in a small team setting, with ability to work independently and collaboratively, while meeting scheduled deadlines in a fast-paced environment.
  • Highly organized, exceptional attention to detail, and strong proficiency in documentation skills.

Highly desirable skills include:

  • Experience developing assays and workflows using MS for biomarker discovery in patient samples.

EDUCATION

PhD in relevant discipline and an additional 3-10 years of laboratory experience following graduate school. Specific title and responsibilities are flexible to match a given candidate’s experience and may involve supervising the work of other scientists and research associates on the team.