Browse our recent publications


Deep, Unbiased Multi-omics Approach for the Identification of Pancreatic Cancer Biomarkers from Blood

Deep, Unbiased Multi-omics Approach for the Identification of Pancreatic Cancer Biomarkers from Blood

This poster, presented at AACR 2022 from Prognomiq, describes a proof-of-concept study using broad phenotypic multi-omics approach to identify known and unknown biomarkers in a pancreatic cancer cohort.
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May
2022

Applications:
Assay Method
Cancer Research

Product: proteograph

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Incorporation of Glycoproteome Detection into Large Scale Unbiased Proteomics Studies Utilizing Nanoparticles

This poster, presented at USHUPO from Prognomiq describes how Seer’s Proteograph™ nanoparticle technology specifically captures unique proteoforms in the corona formation and allow for comprehensive assessment of the circulating glycoproteome.
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Mar
2022

Applications:
Assay Method
Cancer Research

Product: proteograph

deep proteomics studies at scale

Engineered nanoparticles enable deep proteomics studies at scale by leveraging tunable nano–bio interactions

This study examines in detail the relationship between the unique physicochemical properties of a panel of proprietary engineered nanoparticles (NPs) and the diverse pattern of protein sampling that is enabled by a unique nano-bio interface that is created between a given NP surface and a given biological sample.
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Mar
2022

Applications:
Assay Method

Product: proteograph

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Deep and Unbiased Plasma Profiling of Alzheimer’s and Mild Cognitive Impairment Subjects with a Novel Multi-nanoparticle Approach

This work, presented at USHUPO, describes a 200-sample study to classify protein biomarkers for AD and MCI conditions in a rapid, reproducible fashion to enable more powerful clinical studies.
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Mar
2022

Applications:
Neurodegenerative Disease

Product: proteograph

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Deep, Rapid and Unbiased Plasma Proteomics with Differential Analysis of Proteoforms Enabling Proteogenomic Studies in a NSCLC Study

This poster, presented at USHUPO describes a performance evaluation between label-free and tandem mass tag multiplex methods for plasma proteomics. The Proteograph Product Suite enables rapid, automated and reproducible sample prep for larger sample cohorts.
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Mar
2022

Applications:
Cancer Research

Product: proteograph

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Multi-nanoparticle Workflow Enables Deep Plasma Proteomics at Scale with Enhanced Precision and Depth of Coverage

Presented at USHUPO 2022, this study describes how nano-bio interactions may be tuned to optimize the binding and capture of a large and diverse set of proteins, including cytokines and hormone signaling proteins.
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Mar
2022

Applications:
Assay Method

Product: proteograph

Biorxiv_2022_Hornburg

Enhanced competitive protein exchange at the nano-bio interface enables ultra-deep coverage of the human plasma proteome

This article explores the unique capacity of nanoparticles, a key component of the Proteograph Product Suite, to be tuned to interact with proteins by tailored surface functionalization and optimized to enable deeper protein access.
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Jan
2022

Applications:
Assay Method

Product: proteograph

In-Depth Plasma Proteomics Profiling With Nanoparticle-Based Proteograph Workflow: A Performance Evaluation Of Label-Free And TMT Multiplexing Approaches

In-Depth Plasma Proteomics Profiling With Nanoparticle-Based Proteograph Workflow: A Performance Evaluation Of Label-Free And TMT Multiplexing Approaches

This poster presented at the American Society for Mass Spectrometry describes a high-throughput multiplexed workflow for 16 biofluid samples. Plasma proteins across 9 orders of magnitude dynamic range including 40 cytokine activity proteins and several members of the TNF superfamily were identified.
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Nov
2021

Applications:
Assay Method

Product: proteograph

Nanoparticle-Based Method Identifies 2200 Proteins In A Cardiovascular Disease Study Covering Known Biomarkers Among Other Differentially Expressed Proteins

Nanoparticle-Based Method Identifies 2200 Proteins In A Cardiovascular Disease Study Covering Known Biomarkers Among Other Differentially Expressed Proteins

This collaboration with the Broad Institute presented at the American Society for Mass Spectrometry describes a Proteograph™ application for cardiovascular biomarker research using deep plasma proteomics. Over 2000 proteins were detected in each individual patient sample with a total of over 4000 across 16 samples.
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Nov
2021

Applications:
Cardiovascular Research

Product: proteograph

Proteomic Profiling Of Prostate Cancer Plasma Specimens Using Proteograph And TIMS Technology

Proteomic Profiling Of Prostate Cancer Plasma Specimens Using Proteograph And TIMS Technology

This poster presented at the American Society for Mass Spectrometry from Oregon Health Sciences University describes a Proteograph™ application proof-of-concept pilot study on 32 prostate cancer serum specimens retrospectively collected from patients with high and low tumor grades.
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Nov
2021

Applications:
Cancer Research

Product: proteograph