Last Updated
25 October 2022

High-resolution proteomics identifies non-small-cell lung cancer-associated proteoforms

This poster demonstrates how the Proteograph™ Product Suite enables deep, unbiased, rapid, and scalable access to the plasma proteome. The study shows the power of the Proteograph in a proof-of-concept proteoform analysis of 80 healthy controls and 61 early-stage non-small-cell lung cancer (NSCLC) samples to infer proteoforms derived from alternative gene splicing or post-translational cleavage. We identified 20 proteoform candidates, including four that showed differential abundance between NSCLC and control samples. This peptide-centric analyses revealed disease-associated proteoforms that were masked with protein-centric analyses.